Parameter
| Biomarker | miR-486-5p | Full name | microRNA-486-5p | Molecular Type | Nucleic acid (miRNA) |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, prognosis, and prediction of treatment response |
| Disease | Chronic Myeloid Leukemia(CML) | Disease Subtypes | / | ||
| Organ | Blood, bone marrow | Test Sample / Technology Platform | Peripheral blood leukocytes/K562 cells (qRT-PCR) | ||
| Pathobiological Mechanisms | Downregulated in newly diagnosed patients, upregulated after imatinib treatment, with better prognosis and more significant therapeutic response in high-expression patients. | ||||
| Clinical Availability Status | Research validation: Correlated with the Sokar score, enabling early diagnosis of CML. | ||||
| Notes and Dynamics | Exhibits tumor-suppressive effects and regulates the downstream signaling pathway of BCR-ABL. | ||||