Parameter
| Biomarker | HOXA4 gene methylation | Full name | Homeobox A4 gene methylation | Molecular Type | Nucleic acid (DNA methylation) |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Drug resistance prediction, disease progression prediction |
| Disease | Chronic Myeloid Leukemia(CML) | Disease Subtypes | / | ||
| Organ | Blood, bone marrow | Test Sample / Technology Platform | Patient sample (methylation-sensitive high-resolution melting technique) | ||
| Pathobiological Mechanisms | High methylation is associated with imatinib resistance and disease progression to advanced stages, and is correlated with transcription type, smoking, and high Sokal score. | ||||
| Clinical Availability Status | Study verification: The methylation level in the drug-resistant group was significantly higher than that in the well-responsive group. | ||||
| Notes and Dynamics | Epigenetic biomarkers provide a basis for risk stratification. | ||||