Parameter
| Biomarker | MDM2 gene variants (SNP309) | Full name | Mouse Double Minute 2 Homolog gene variants (Single Nucleotide Polymorphism 309) | Molecular Type | Nucleic acid (gene) |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Response prediction and prognosis |
| Disease | Chronic Myeloid Leukemia(CML) | Disease Subtypes | / | ||
| Organ | Blood, bone marrow | Test Sample / Technology Platform | Whole blood (genotyping) | ||
| Pathobiological Mechanisms | The SNP309 G/G genotype is associated with the risk of molecular response failure and interacts with the TP53 SNP215 combination to influence prognosis | ||||
| Clinical Availability Status | Study validation: Specific genotype combinations are associated with treatment response and survival rates. | ||||
| Notes and Dynamics | Provide reference for individualized TKI treatment regimen formulation. | ||||