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133

Parameter
Biomarker IL-10/IL-6 ratio Full name interleukin-10/interleukin-6 ratio Molecular Type Protein composition
Molecular Formula Molecular Weight Core Functional Dimensions Diagnosis, prognosis
Disease Non-Hodgkin Lymphoma (NHL) Disease Subtypes /
Organ Lymphoid tissue Test Sample / Technology Platform Serum, cerebrospinal fluid (cellular microbead array)
Pathobiological Mechanisms A ratio ≥2.30 predicts SCNSL risk and adverse PFS
Clinical Availability Status Validation phase of the study: 56 patients were validated, requiring multicenter and alternative sample testing for exploration.
Notes and Dynamics Validation of multicenter value and exploration of serum as a potential alternative to cerebrospinal fluid testing.

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This study was supported by the Scientific Research Innovation Capability Support Project for Young Faculty (SRICSPYF-ZY2025112), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM612)

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