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207

Parameter
Biomarker NMP22 Full name Nuclear Matrix Protein 22 Molecular Type Protein (nuclear-matrix protein)
Molecular Formula / Molecular Weight / Core Functional Dimensions Diagnosis (apoptosis-related)
Disease Bladder Cancer (BC) Disease Subtypes /
Organ Bladder Test Sample / Technology Platform Urine (NMP22® assay kit)
Pathobiological Mechanisms Quantifies NMP22 released during tumor-cell apoptosis; sensitivity superior to cytology
Clinical Availability Status FDA-cleared; clinic-ready quantitative kit
Notes and Dynamics False positives in cystitis, BPH or after instrumentation; recommend adjuvant use

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This study was supported by the Scientific Research Innovation Capability Support Project for Young Faculty (SRICSPYF-ZY2025112), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM612)

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