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208

Parameter
Biomarker ECRG4 gene promoter methylation Full name Esophageal Cancer Related Gene 4 gene promoter methylation Molecular Type Nucleic acid (DNA methylation)
Molecular Formula / Molecular Weight / Core Functional Dimensions Early diagnosis (epigenetic)
Disease Bladder Cancer (BC) Disease Subtypes /
Organ Bladder Test Sample / Technology Platform Urine (qMSP)
Pathobiological Mechanisms Tumour-suppressor gene; promoter hyper-methylation occurs early; detectable in urine for screening
Clinical Availability Status Research verification stage
Notes and Dynamics Early epigenetic event; sensitivity improved when combined with ITIH5 methylation

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This study was supported by the Scientific Research Innovation Capability Support Project for Young Faculty (SRICSPYF-ZY2025112), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM612)

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