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Parameter
Biomarker ITIH5 gene promoter methylation Full name Inter-α-trypsin inhibitor heavy chain 5 gene promoter methylation Molecular Type Nucleic acid (DNA methylation)
Molecular Formula / Molecular Weight / Core Functional Dimensions Early non-invasive diagnosis
Disease Bladder Cancer (BC) Disease Subtypes /
Organ Bladder Test Sample / Technology Platform Urine (qMSP, dPCR)
Pathobiological Mechanisms Tumour-suppressor; methylation detectable in urine cfDNA; combinatorial assay increases performance
Clinical Availability Status Research verification stage
Notes and Dynamics Combined EI-BLA test reaches 64–70 % sensitivity & 97 % specificity

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This study was supported by the Scientific Research Innovation Capability Support Project for Young Faculty (SRICSPYF-ZY2025112), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM612)

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