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259

Parameter
Biomarker mePENK Full name Methylated proenkephalin gene Molecular Type Nucleic acid (DNA methylation)
Molecular Formula / Molecular Weight / Core Functional Dimensions Early diagnosis
Disease Bladder Cancer (BC) Disease Subtypes /
Organ Bladder Test Sample / Technology Platform Urine (exact methylation platform not specified)
Pathobiological Mechanisms Early epigenetic event in BCa; methylation status in urine serves as a non-invasive biomarker for early detection and improves detection efficacy
Clinical Availability Status Research verification stage: focused on early BCa; large-sample validation required
Notes and Dynamics Pro-enkephalin gene offering an important epigenetic urine marker for early non-invasive diagnosis of BCa

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This study was supported by the Scientific Research Innovation Capability Support Project for Young Faculty (SRICSPYF-ZY2025112), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM612)

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