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Parameter
Biomarker CSF1、ICAM1、IL-18BP、KIM1、TNFRII Full name Colony Stimulating Factor 1 / Intercellular Adhesion Molecule 1 / Interleukin-18 Binding Protein / Kidney Injury Molecule 1 / Tumor Necrosis Factor Receptor II composite biomarker score Molecular Type Protein combination
Molecular Formula / Molecular Weight / Core Functional Dimensions Predicting treatment response
Disease Renal Cell Carcinoma(RCC) Disease Subtypes /
Organ Kidney Test Sample / Technology Platform Serum(Multivariate detection platform)
Pathobiological Mechanisms Covering multiple pathways including inflammation and angiogenesis, it comprehensively reflects the biological characteristics of tumors.
Clinical Availability Status Study test: Validation in the RECORD-3 trial
Notes and Dynamics Specific prediction of therapeutic benefit with everolimus, significantly longer PFS in patients with high CBS

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This study was supported by the Scientific Research Innovation Capability Support Project for Young Faculty (SRICSPYF-ZY2025112), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM612)

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