Parameter
| Biomarker | CA-IX | Full name | Carbonic Anhydrase IX | Molecular Type | Protein（transmembrane protein） |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, classification, and targeted therapy targets |
| Disease | Renal Cell Carcinoma(RCC) | Disease Subtypes | / | ||
| Organ | Kidney | Test Sample / Technology Platform | Tissue (immunohistochemistry), Serum (ELISA), Imaging (PET/CT) | ||
| Pathobiological Mechanisms | Downstream molecules of the VHL mutation pathway, which are highly expressed in ccRCC and lowly expressed in normal renal tissue | ||||
| Clinical Availability Status | Clinical validation / Multi-scenario application: Immunohistochemistry for typing; 124I-cG250 PET/CT for diagnosis | ||||
| Notes and Dynamics | 18F-VM4-037 PET/CT improves detection of metastatic ccRCC; cccRCC shows characteristic "cup-shaped" staining | ||||