Parameter
| Biomarker | T | Full name | Testosterone | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | C₁₉H₂₈O₂ | Molecular Weight | 288.42 g/mol | Core Functional Dimensions | Diagnosis, Monitoring |
| Disease | PCOS | Disease Subtypes | / | ||
| Organ | Ovary | Test Sample / Technology Platform | Serum (CLIA, RIA, LC-MS/MS) | ||
| Pathobiological Mechanisms | Clinical routine application: Incorporate the "hyperandrogenemia" indicator as stipulated in the Rotterdam criteria for diagnosing PCOS. | ||||
| Clinical Availability Status | In patients with PCOS, the ovarian stromal cells and adrenal glands secrete excessive androgens. Excessive testosterone inhibits follicular development, causing ovulation disorders, and simultaneously triggers hyperandrogenic manifestations such as hirsutism and acne. | ||||
| Notes and Dynamics | It is necessary to distinguish between total testosterone and free testosterone (free testosterone better reflects biological activity); approximately 20%-30% of PCOS patients have normal total testosterone levels but elevated free testosterone, and the free testosterone index (FAI) needs to be calculated in combination with SHBG. | ||||