Parameter
| Biomarker | miR-18b | Full name | MicroRNA-18b | Molecular Type | microRNA |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, Prediction |
| Disease | PCOS | Disease Subtypes | / | ||
| Organ | Ovary | Test Sample / Technology Platform | Serum / Follicular fluid (real-time fluorescence quantitative PCR qRT-PCR, small RNA sequencing, dPCR) | ||
| Pathobiological Mechanisms | By targeting and regulating genes related to the insulin signaling pathway (such as IRS-1) or genes in the sex hormone synthesis pathway (such as CYP17A1), it affects insulin sensitivity and ovarian androgen secretion. The expression levels are significantly abnormal in the serum and follicular fluid of PCOS patients. | ||||
| Clinical Availability Status | Frontier research stage: Multiple cohorts have confirmed the expression differences, and clinical translation verification is underway. | ||||
| Notes and Dynamics | The expression of miR-18b is downregulated in patients with PCOS and insulin resistance, and it is negatively correlated with fasting insulin and HOMA-IR (r = -0.58, P < 0.001); it is expected to serve as an early predictive marker for "metabolic PCOS". | ||||