Parameter
| Biomarker | SHBG | Full name | Sex hormone-binding globulin | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Monitoring |
| Disease | PCOS | Disease Subtypes | / | ||
| Organ | Ovary | Test Sample / Technology Platform | Serum (immunoturbidimetry, ELISA) | ||
| Pathobiological Mechanisms | It is mainly synthesized by the liver and can specifically bind to testosterone (reducing the activity of free testosterone); in patients with PCOS, due to insulin resistance, the synthesis of SHBG in the liver is inhibited, resulting in a decrease in SHBG levels and a relative increase in free testosterone. | ||||
| Clinical Availability Status | Clinical routine use: To assist in evaluating hyperandrogenic activity and insulin resistance. | ||||
| Notes and Dynamics | SHBG is significantly negatively correlated with insulin resistance (r = -0.62, P < 0.001), and can be used as an alternative indicator for "insulin-resistant PCOS"; the free testosterone index (FAI = total testosterone / SHBG × 100) is more capable of reflecting the biological effects of hyperandrogenism than total testosterone alone. | ||||