Parameter
| Biomarker | HPV | Full name | Human papillomavirus | Molecular Type | Nucleic acid |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Screening, Diagnosis |
| Disease | Cervical Cancer | Disease Subtypes | / | ||
| Organ | Cervix | Test Sample / Technology Platform | Cervical exfoliated cells (PCR, HC2 hybrid capture, NGS typing) | ||
| Pathobiological Mechanisms | High-risk HPV (types 16/18/31/33, etc.) integrates its genome into the host cell, causing abnormalities in the p53 and Rb pathways, and driving carcinogenesis. | ||||
| Clinical Availability Status | Clinical routine screening / guideline recommendation: Core indicators for population screening, incorporated into the cervical cancer triage prevention system. | ||||
| Notes and Dynamics | Women with negative HPV status have an extremely low risk of developing cervical cancer (the negative predictive value is over 99%); combined with TCT/liquid-based cytology can significantly increase the detection rate of precancerous lesions. | ||||