Parameter
| Biomarker | P16INK4a | Full name | Cyclin-dependent kinase inhibitor 2A | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis |
| Disease | Cervical Cancer | Disease Subtypes | / | ||
| Organ | Cervix | Test Sample / Technology Platform | Cervical exfoliated cells / Tumor tissue (IHC, immunocytochemistry) | ||
| Pathobiological Mechanisms | CDK4/6 inhibitors, after HPV infection, the E7 protein inhibits the Rb pathway, leading to compensatory overexpression of P16INK4a. | ||||
| Clinical Availability Status | Clinical routine diversion tools: Core diversion indicators for HPV-positive individuals | ||||
| Notes and Dynamics | The combined detection with Ki-67 (P16/Ki-67 double positive) has a sensitivity of 95% for the diagnosis of high-grade squamous intraepithelial lesions (HSIL), reducing overdiagnosis. | ||||