Parameter
| Biomarker | MEG3 | Full name | Maternal expressed gene 3 | Molecular Type | Nucleic acid（lncRNA） |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, prognosis |
| Disease | Cervical Cancer | Disease Subtypes | / | ||
| Organ | Cervix | Test Sample / Technology Platform | Tumor tissue / Serum (RT-PCR, RNA sequencing, digital PCR) | ||
| Pathobiological Mechanisms | Tumor suppressor long non-coding RNA inhibits tumor proliferation by regulating the p53 pathway, and its expression is significantly downregulated in cervical cancer. | ||||
| Clinical Availability Status | Frontier Research: Potential Biomarkers for Liquid Biopsy, Undergoing Large-scale Cohort Validation. | ||||
| Notes and Dynamics | The serum MEG3 level is negatively correlated with tumor stage and differentiation degree; combined with RASSF1A methylation detection, the early diagnosis AUC value reaches 0.89. | ||||