Parameter
| Biomarker | RASSF1A | Full name | Ras association domain family 1 isoform A | Molecular Type | Nucleic acid（DNA） |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, prognosis |
| Disease | Cervical Cancer | Disease Subtypes | / | ||
| Organ | Cervix | Test Sample / Technology Platform | Tumor tissue / Serum (Methylated-specific PCR, NGS, Pyrosequencing) | ||
| Pathobiological Mechanisms | Tumor suppressor genes, whose promoters are methylated, result in silencing of expression and loss of functions related to cell cycle regulation and apoptosis induction. | ||||
| Clinical Availability Status | Research validation stage: The early diagnostic value has been confirmed in multiple cohorts. | ||||
| Notes and Dynamics | Abnormal methylation can occur during the precancerous stage of cervical cancer, indicating a risk of cancer formation up to 6-12 months earlier than HPV testing; serum testing is non-invasive and convenient. | ||||