Parameter
| Biomarker | HE4 | Full name | Human epididymis protein 4 | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis |
| Disease | Ovarian Cancer | Disease Subtypes | / | ||
| Organ | Ovary | Test Sample / Technology Platform | Serum (combined detection using ELISA, CLIA, and ROMA algorithms) | ||
| Pathobiological Mechanisms | It belongs to the protease inhibitor superfamily and is involved in the proliferation, invasion and anti-apoptosis of tumor cells. It is highly specifically expressed in ovarian cancer. | ||||
| Clinical Availability Status | Clinical routine / guideline recommendation: FDA-approved for ovarian cancer risk assessment, core components of the ROMA algorithm. | ||||
| Notes and Dynamics | Specificity (approximately 90%) is significantly superior to CA-125. When combined with CA-125, the detection method has an AUC value of 0.88-0.92 for stage I ovarian cancer, effectively reducing the false positive rate. | ||||