Parameter
| Biomarker | RASSF1A | Full name | Ras association domain family 1 isoform A | Molecular Type | Nucleic acid（DNA） |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, prognosis |
| Disease | Ovarian Cancer | Disease Subtypes | / | ||
| Organ | Ovary | Test Sample / Technology Platform | Serum (circulating free DNA) / Tumor tissue (methylated specific PCR, NGS) | ||
| Pathobiological Mechanisms | It is a tumor suppressor gene. The methylation of the promoter leads to the silencing of expression, resulting in the loss of cell cycle regulation and apoptosis induction functions, thereby promoting the occurrence and development of ovarian cancer. | ||||
| Clinical Availability Status | Research validation / Early clinical: A large-scale cohort study was conducted to verify its early diagnostic value, but it has not yet been widely adopted. | ||||
| Notes and Dynamics | Ovarian cancer can exhibit abnormal methylation even at an early stage. Combined with HE4 testing, the diagnostic sensitivity for stage I can be increased to 76%. It is a core candidate for epigenetic biomarkers in liquid biopsy. | ||||