Parameter
| Biomarker | FOLR1 | Full name | Folate receptor 1 | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis |
| Disease | Ovarian Cancer | Disease Subtypes | / | ||
| Organ | Ovary | Test Sample / Technology Platform | Tumor tissue / Serum (IHC, ELISA, PET-CT imaging) | ||
| Pathobiological Mechanisms | It mediates the uptake of folic acid, meeting the metabolic demands for the rapid proliferation of ovarian cancer cells, and is highly specifically expressed in ovarian cancer tissues. | ||||
| Clinical Availability Status | Clinical translation / Companion diagnostics for targeted therapy: IHC for patient screening, and in the clinical application of targeted drugs. | ||||
| Notes and Dynamics | FOLR1-targeted ADCs (such as Mirvetuximab Soravtansine) have been approved for the treatment of platinum-resistant ovarian cancer; PET-CT imaging can achieve the integration of tumor localization and efficacy assessment. | ||||