Parameter
| Biomarker | TP53 | Full name | Tumor protein p53 | Molecular Type | Protein / Nucleic acid（DNA/RNA） |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Prognosis |
| Disease | Breast Cancer | Disease Subtypes | / | ||
| Organ | Breast | Test Sample / Technology Platform | Tumor tissues (IHC: protein expression; NGS: gene mutations) | ||
| Pathobiological Mechanisms | TP53 is a tumor suppressor gene. When it mutates, it loses its functions of regulating the cell cycle and inducing apoptosis, leading to an increase in the malignancy of tumor cells and resistance to chemotherapy. | ||||
| Clinical Availability Status | Research verification / Clinical reference: TP53 mutations are associated with poor prognosis in breast cancer and can be used as a predictor of chemotherapy sensitivity. | ||||
| Notes and Dynamics | TP53-targeted drugs (such as PRIMA-1MET) are currently in the clinical trial stage for advanced breast cancer with TP53 mutations. | ||||