Parameter
| Biomarker | RASSF1A | Full name | Ras association domain family 1 isoform A | Molecular Type | Nucleic acid（DNA） |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, prognosis |
| Disease | Breast Cancer | Disease Subtypes | / | ||
| Organ | Breast | Test Sample / Technology Platform | Tumor tissue / Serum (Methylated Specific PCR MS-PCR, NGS) | ||
| Pathobiological Mechanisms | RASSF1A is a tumor suppressor gene. The methylation of its promoter leads to gene silencing, resulting in the loss of its inhibitory effect on cell proliferation, and is associated with the occurrence and metastasis of breast cancer. | ||||
| Clinical Availability Status | Research verification: Methylization detection shows potential in the early diagnosis and prognosis assessment of triple-negative breast cancer, but has not yet been widely applied in clinical practice. | ||||
| Notes and Dynamics | The methylation of RASSF1A can serve as a biomarker for liquid biopsy, used for early screening and recurrence monitoring. Relevant validation studies are currently underway. | ||||