Parameter
| Biomarker | E-cadherin | Full name | Cadherin-1 | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Monitoring, prognosis |
| Disease | Breast Cancer | Disease Subtypes | / | ||
| Organ | Breast | Test Sample / Technology Platform | Tumor tissue (IHC, IF) | ||
| Pathobiological Mechanisms | E-cadherin mediates the adhesion between epithelial cells. Its expression being downregulated or lost leads to the disruption of cell-cell connections, promoting tumor epithelial-mesenchymal transition (EMT) and metastasis. | ||||
| Clinical Availability Status | Research verification / Clinical reference: Low expression of E-cadherin is associated with an increased risk of lymph node metastasis and distant metastasis in breast cancer. | ||||
| Notes and Dynamics | The expression status of E-cadherin can serve as an indicator for risk stratification of metastasis, guiding the intensity of postoperative adjuvant therapy. | ||||