Parameter
| Biomarker | Beclin 1 | Full name | Beclin 1 autophagy related | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Prognosis |
| Disease | Breast Cancer | Disease Subtypes | / | ||
| Organ | Breast | Test Sample / Technology Platform | Tumor tissues (IHC, Western Blot) | ||
| Pathobiological Mechanisms | Beclin 1 is a key protein for initiating autophagy. In breast cancer, the expression of Beclin 1 is abnormal (either high or low expression is possible), and it affects the survival of tumor cells and chemotherapy resistance through regulating autophagy. | ||||
| Clinical Availability Status | Research verification: The expression status of Beclin 1 is correlated with the chemosensitivity of breast cancer. Low expression may indicate chemotherapy resistance. | ||||
| Notes and Dynamics | The use of autophagy inhibitors (such as hydroxychloroquine) in combination with chemotherapy to explore therapeutic value in patients with abnormal Beclin 1 expression. | ||||