Parameter
| Biomarker | CTNNB1 | Full name | Catenin beta 1 | Molecular Type | Nucleic acid（DNA） |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Prognosis |
| Disease | Endometrial Cancer | Disease Subtypes | / | ||
| Organ | Endometrium | Test Sample / Technology Platform | Organization (IHC, NGS) | ||
| Pathobiological Mechanisms | The β-catenin encoding protein, when mutated, leads to the obstruction of protein degradation and its accumulation in the nucleus, activating the Wnt/β-catenin pathway and driving tumor formation. | ||||
| Clinical Availability Status | Study verification (subtype classification): Mutations are more commonly found in low-grade endometrioid carcinomas and are associated with high differentiation and low invasiveness. | ||||
| Notes and Dynamics | It can serve as an auxiliary indicator for differentiating endometrioid carcinoma from other subtypes, and patients with the mutant type have a better prognosis. | ||||