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Parameter
Biomarker PHI Full name Prostate Health Index Molecular Type Protein
Molecular Formula / Molecular Weight / Core Functional Dimensions Susceptibility, diagnosis
Disease PCa Disease Subtypes /
Organ Prostate Test Sample / Technology Platform Serum (ELISA; RIA)
Pathobiological Mechanisms It integrates measurements of three different forms of PSA to provide a composite score for more accurate assessment of a patient's risk of clinically significant prostate cancer.
Clinical Availability Status Clinical routine
Notes and Dynamics PHI demonstrates superior differentiation between prostate cancer and BPH with a 39% threshold. However, it remains dependent on PSA and cannot fully overcome some of PSA's limitations.

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This study was supported by the Scientific Research Innovation Capability Support Project for Young Faculty (SRICSPYF-ZY2025112), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM612)

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