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717

Parameter
Biomarker DHEA/DHEAS Full name Dehydroepiandrosterone (sulfate) Molecular Type hormone
Molecular Formula C₁₉H₂₈O₂ / C₁₉H₂₈O₅S Molecular Weight 288.42 / 368.49 Core Functional Dimensions Diagnosis and Prognosis
Disease Adrenocortical Carcinoma Disease Subtypes /
Organ Adrenal Cortex Test Sample / Technology Platform Serum (immunoassay, LC-MS/MS)
Pathobiological Mechanisms Adrenal cortical androgen precursor, tumor cells abnormal synthetic release, reflect the tumor load
Clinical Availability Status Clinical routine application: the core detection indicators of patients with virilization symptoms increased significantly in cancer patients than in benign lesions, which are used for the differentiation of benign and malignant
Notes and Dynamics And androstenedione joint detection can improve diagnostic sensitivity, higher level is associated with tumor invasive

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This study was supported by the Scientific Research Innovation Capability Support Project for Young Faculty (SRICSPYF-ZY2025112), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM612)

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