Parameter
| Biomarker | TP53 | Full name | TP53 gene mutation | Molecular Type | Nucleic acid (DNA) |
|---|---|---|---|---|---|
| Molecular Formula | Macromolecule | Molecular Weight | / | Core Functional Dimensions | Diagnosis and prognosis |
| Disease | Adrenocortical Carcinoma | Disease Subtypes | / | ||
| Organ | Adrenal Cortex | Test Sample / Technology Platform | Tissues (NGS, Sanger sequencing, IHC) | ||
| Pathobiological Mechanisms | Tumor suppressor genes, mutations that lead to uncontrolled cell cycle, enhance tumor invasiveness and metastasis | ||||
| Clinical Availability Status | Clinical validation: about 20% - 40% of adrenal cortical carcinoma is mutation, TuBianZhe prognosis is poor, used to differentiate benign and malignancy | ||||
| Notes and Dynamics | Mutually exclusive and CTNNB1 mutations, are at high risk of cancer molecular characteristics, can guide the chemotherapy scheme selection | ||||