Parameter
| Biomarker | CTNNB1 | Full name | β-catenin gene | Molecular Type | Nucleic acid (DNA) |
|---|---|---|---|---|---|
| Molecular Formula | Macromolecule | Molecular Weight | / | Core Functional Dimensions | Diagnosis, typing |
| Disease | Adrenocortical Carcinoma | Disease Subtypes | / | ||
| Organ | Adrenal Cortex | Test Sample / Technology Platform | Tissues (NGS, IHC) | ||
| Pathobiological Mechanisms | Encoding β-catenin, mutation activates Wnt pathway and promotes tumor proliferation and invasion | ||||
| Clinical Availability Status | Clinical application: about 10%-20% of cancers have mutation, which is more common in the cortisol secreting type. IHC detection of nuclear β-catenin expression can assist in diagnosis | ||||
| Notes and Dynamics | The mutation is associated with poor differentiation of tumors, which can be used as a potential target for targeted therapy | ||||