Parameter
| Biomarker | TERT | Full name | Telomerase reverse transcriptase | Molecular Type | Nucleic acid (DNA) |
|---|---|---|---|---|---|
| Molecular Formula | Macromolecule | Molecular Weight | / | Core Functional Dimensions | Prognosis, Monitoring |
| Disease | Adrenocortical Carcinoma | Disease Subtypes | / | ||
| Organ | Adrenal Cortex | Test Sample / Technology Platform | Tissue/serum cfDNA (NGS, FISH) | ||
| Pathobiological Mechanisms | Telomerase reverse transcriptase, promoter mutation or amplification elongates telomeres, promoting tumor immortalization | ||||
| Clinical Availability Status | Clinical validation: TuBianZhe tumor invasive strong, high recurrence rate, cfDNA detection dynamically monitoring of disease progression | ||||
| Notes and Dynamics | TERT mutation detection by liquid biopsy is the frontier of non-invasive recurrence monitoring | ||||