Parameter
| Biomarker | p53 (mutant) | Full name | Mutant p53 protein | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | Macromolecule | Molecular Weight | / | Core Functional Dimensions | Diagnosis, Prognosis |
| Disease | Adrenocortical Carcinoma | Disease Subtypes | / | ||
| Organ | Adrenal Cortex | Test Sample / Technology Platform | Tissue (immunohistochemical IHC) | ||
| Pathobiological Mechanisms | TP53 gene expression product of mutant p53, loss of tumor suppressor function, to promote tumor progression | ||||
| Clinical Availability Status | Clinical routine application: IHC testing mutant p53 expression, positive suggests high malignant degree, used for prognosis evaluation | ||||
| Notes and Dynamics | Combined detection with Ki-67 can improve the screening efficiency of high-risk patients | ||||