Parameter
| Biomarker | SPDEF | Full name | SAM Pointed Domain-containing ETS Transcription Factor | Molecular Type | Nucleic acid |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnose |
| Disease | PCa | Disease Subtypes | / | ||
| Organ | Prostate | Test Sample / Technology Platform | Serum and plasma (MSRE-PCR, qPCR) | ||
| Pathobiological Mechanisms | A specific CpG site in the promoter region of SPDEF gene was significantly hypomethylated in the blood leukocyte DNA of PCa patients, and the hypomethylation degree was positively correlated with the malignancy of the tumor. | ||||
| Clinical Availability Status | Research verification | ||||
| Notes and Dynamics | The specific molecular mechanisms by which low SPDEF methylation drives prostate cancer progression require experimental validation | ||||