Parameter
| Biomarker | GRPR | Full name | Gastrin-Releasing Peptide Receptor | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, prognosis, risk stratification |
| Disease | PCa | Disease Subtypes | / | ||
| Organ | Prostate | Test Sample / Technology Platform | Tumor tissue (PET-CT、PET-MRI) | ||
| Pathobiological Mechanisms | The activation of the GRP/GRPR signaling pathway promotes tumor cell proliferation. In CRPC, this pathway upregulates androgen receptor variants by activating the NF-κB signaling pathway, leading to resistance to androgen deprivation therapy. | ||||
| Clinical Availability Status | Clinical research | ||||
| Notes and Dynamics | Physiological expression in some benign prostate tissues may lead to false positives; its expression is affected by prior treatments (e.g., ADT) and requires patient screening. | ||||