Parameter
| Biomarker | DNA methylation (BRCA1, RAD51C, PALB2, RAD54B, SYCP3) | Full name | DNA methylation (BRCA1, RAD51C, PALB2, RAD54B, SYCP3) | Molecular Type | Nucleic acid DNA methylation |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Classification, staging, prognosis |
| Disease | TGCT | Disease Subtypes | / | ||
| Organ | Testis | Test Sample / Technology Platform | Tumor tissue (TCGA, patient cohort validation) | ||
| Pathobiological Mechanisms | The hypermethylation of homologous recombination repair gene leads to gene silencing and genomic instability. | ||||
| Clinical Availability Status | Stage of research | ||||
| Notes and Dynamics | Its methylation status can predict the therapeutic response to PARP inhibitors, demonstrating significant translational potential. | ||||