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Parameter
Biomarker C4 Full name Complement 4 Molecular Type Proteins (complement)
Molecular Formula / Molecular Weight / Core Functional Dimensions Diagnosis and condition assessment
Disease Autoimmune Disease (AD) Disease Subtypes /
Organ Spleen, thymus, lymphoid tissue Test Sample / Technology Platform Serum (complement quantification)
Pathobiological Mechanisms Complement levels reflect the degree of immune activation and consumption.
Clinical Availability Status Clinically applied for diagnosis/activity assessment; reduction precedes C3, 45% 3-year recurrence rate in persistent low levels
Notes and Dynamics Low levels correlate with disease activity; independent risk factor.

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This study was supported by the Scientific Research Innovation Capability Support Project for Young Faculty (SRICSPYF-ZY2025112), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM612)

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