Parameter
| Biomarker | ADAMTS-2 | Full name | A Disintegrin And Metalloproteinase with Thrombospondin Motifs 2 | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis |
| Disease | Autoimmune Disease (AD) | Disease Subtypes | / | ||
| Organ | Spleen, thymus, lymphoid tissue | Test Sample / Technology Platform | Peripheral blood mononuclear cells (RT-qPCR) | ||
| Pathobiological Mechanisms | Upregulated expression in peripheral blood mononuclear cells, involved in inflammation regulation, and enriched in the TNF-α signaling via NF-κB pathway. | ||||
| Clinical Availability Status | Research validation: AUC=0.805, capable of distinguishing newly diagnosed SLE from RA and healthy controls. | ||||
| Notes and Dynamics | Associated with immune cell infiltration, it holds promise as a novel therapeutic target. | ||||