Parameter
| Biomarker | SIGLEC1 | Full name | Sialic Acid-Binding Immunoglobulin-Like Lectin 1 | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis and exclusion of suspected cases |
| Disease | Autoimmune Disease (AD) | Disease Subtypes | / | ||
| Organ | Spleen, thymus, lymphoid tissue | Test Sample / Technology Platform | Peripheral blood (flow cytometry) | ||
| Pathobiological Mechanisms | Associated with IFN-γ pathway activation, significantly elevated in SLE patients, negative results can effectively exclude SLE. | ||||
| Clinical Availability Status | Research validation: Sensitivity 98.7%, Specificity 82.1%, AUC=0.95. | ||||
| Notes and Dynamics | It demonstrates superior diagnostic accuracy compared to ANA, C3, and C4, serving as an efficient exclusionary diagnostic marker. | ||||