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Parameter
Biomarker CD226⁺ B cell Full name Cluster of Differentiation 226-positive B lymphocyte Molecular Type Subpopulation of immune cells
Molecular Formula / Molecular Weight / Core Functional Dimensions Assessment of disease activity and prognosis
Disease Autoimmune Disease (AD) Disease Subtypes /
Organ Spleen, thymus, lymphoid tissue Test Sample / Technology Platform Peripheral blood (flow cytometry)
Pathobiological Mechanisms The proportion was significantly elevated in SLE patients and showed a positive correlation with the SLEDAI-2K score and anti-dsDNA antibody titer.
Clinical Availability Status Study validation: The baseline ratio is associated with prognosis 12 months later, with a higher proportion observed in patients with renal involvement.
Notes and Dynamics Provide reference for therapeutic efficacy evaluation and prognosis assessment.

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This study was supported by the Scientific Research Innovation Capability Support Project for Young Faculty (SRICSPYF-ZY2025112), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM612)

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