Parameter
| Biomarker | HMGB-1 | Full name | High Mobility Group Box 1 | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, disease activity monitoring |
| Disease | Autoimmune Disease (AD) | Disease Subtypes | / | ||
| Organ | Spleen, thymus, lymphoid tissue | Test Sample / Technology Platform | Serum (ELISA) | ||
| Pathobiological Mechanisms | Significantly upregulated in the serum of SLE patients, released through necroptosis and ferroptosis, and positively correlated with disease activity and renal involvement. | ||||
| Clinical Availability Status | Research validation: AUC demonstrates excellent performance as an independent risk factor. | ||||
| Notes and Dynamics | Strongly correlated with RIPK3/MLKL and ferroptosis metabolite levels, demonstrating outstanding diagnostic and monitoring value. | ||||