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Parameter
Biomarker Anti-HSP90α IgG Full name Anti-Heat Shock Protein 90 Alpha Immunoglobulin G Molecular Type Protein
Molecular Formula / Molecular Weight / Core Functional Dimensions APS risk assessment
Disease Autoimmune Disease (AD) Disease Subtypes /
Organ Spleen, thymus, lymphoid tissue Test Sample / Technology Platform Plasma, serum (ELISA)
Pathobiological Mechanisms Decreased levels in patients with SLE secondary to APS can inhibit platelet activation and regulate immune thrombosis.
Clinical Availability Status Research validation: Both exploratory and confirmatory cohorts have confirmed its association with APS risk.
Notes and Dynamics Evaluation of potential biomarkers for assessing the risk of APS in patients with SLE.

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This study was supported by the Scientific Research Innovation Capability Support Project for Young Faculty (SRICSPYF-ZY2025112), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM612)

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