Parameter
| Biomarker | USP48/BRAF | Full name | USP48 / BRAF gene mutation | Molecular Type | Nucleic acid (DNA) |
|---|---|---|---|---|---|
| Molecular Formula | Macromolecule | Molecular Weight | / | Core Functional Dimensions | |
| Disease | Pituitary Adenoma | Disease Subtypes | / | ||
| Organ | Pituitary | Test Sample / Technology Platform | Organization (NGS) | ||
| Pathobiological Mechanisms | Activation of MAPK USP48 mutations, mutated BRAF V600E promote POMC expression | ||||
| Clinical Availability Status | Clinical validation: USP8 wild-type ACTHPA mutation rate in the 23% / 16% respectively, and the associated with invasive | ||||
| Notes and Dynamics | Provide new targets for targeted therapy | ||||