Parameter
| Biomarker | ADAMTS-2 | Full name | A Disintegrin And Metalloproteinase with Thrombospondin Motifs 2 (procollagen N-protease) | Molecular Type | Protein (procollagen N-protease) |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, pathogenesis-related |
| Disease | Autoimmune Disease (AD) | Disease Subtypes | / | ||
| Organ | Spleen, thymus, lymphoid tissue | Test Sample / Technology Platform | Peripheral blood mononuclear cells (RT-qPCR) | ||
| Pathobiological Mechanisms | The expression in PBMCs was significantly higher than in RA patients and healthy controls (HC), enriched in the TNFα signaling via NF-κB pathway. | ||||
| Clinical Availability Status | Research validation: AUC=0.805, correlated with multiple immune cell and laboratory indicators. | ||||
| Notes and Dynamics | May emerge as a novel therapeutic target for SLE. | ||||