Parameter
| Biomarker | PGRN | Full name | Progranulin | Molecular Type | Protein (growth factor-like molecule) |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, pathogenesis-related |
| Disease | Autoimmune Disease (AD) | Disease Subtypes | / | ||
| Organ | Spleen, thymus, lymphoid tissue | Test Sample / Technology Platform | Serum (laboratory test) | ||
| Pathobiological Mechanisms | Elevated serum levels participate in inflammatory responses and renal injury, mediating the pathogenesis of SLE | ||||
| Clinical Availability Status | Research Verification: PGRN knockout mice exhibited reduced anti-dsDNA antibody levels and Less Severe Renal Injury | ||||
| Notes and Dynamics | Key mediators in the pathogenesis of SLE. | ||||