Parameter
| Biomarker | SYP | Full name | Synaptophysin | Molecular Type | Proteins |
|---|---|---|---|---|---|
| Molecular Formula | Macromolecule | Molecular Weight | / | Core Functional Dimensions | Diagnosis (confirmation of neuroendocrine differentiation) |
| Disease | Pancreatic Neuroendocrine Tumors | Disease Subtypes | / | ||
| Organ | Pancreas | Test Sample / Technology Platform | Tissue (immunohistochemical IHC) | ||
| Pathobiological Mechanisms | Synaptic vesicle membrane protein, involved in neurotransmitter release, is a core marker of neuroendocrine lineage | ||||
| Clinical Availability Status | Clinical gold standard: it needs to be combined with CgA to confirm neuroendocrine differentiation, and the positive rate is nearly 100%, without subtype specificity | ||||
| Notes and Dynamics | It may still be positive in poorly differentiated tumors and is a key marker for identifying non-neuroendocrine tumors | ||||