Parameter
| Biomarker | MEN1 | Full name | Multiple endocrine neoplasia type 1 gene | Molecular Type | Nucleic acid (DNA) |
|---|---|---|---|---|---|
| Molecular Formula | Macromolecule | Molecular Weight | / | Core Functional Dimensions | Susceptibility, prognosis |
| Disease | Pancreatic Neuroendocrine Tumors | Disease Subtypes | / | ||
| Organ | Pancreas | Test Sample / Technology Platform | Whole blood/tissue (gene sequencing, IHC) | ||
| Pathobiological Mechanisms | It encodes menin protein, which regulates histone methylation and cell cycle, and mutations lead to uncontrolled cell proliferation | ||||
| Clinical Availability Status | Clinical available (risk assessment and prognostic stratification) : 44% of sporadic PanNET mutation, TuBianZhe relatively good prognosis; Core indicators for screening familial MEN1 syndrome | ||||
| Notes and Dynamics | Combined with DAXX/ATRX mutation, the risk stratification model can be optimized | ||||