Parameter
| Biomarker | DAXX/ATRX | Full name | Death domain-associated protein / ATRX chromatin remodeler | Molecular Type | Nucleic acid (DNA) |
|---|---|---|---|---|---|
| Molecular Formula | Macromolecule | Molecular Weight | / | Core Functional Dimensions | Prognosis and differential diagnosis |
| Disease | Pancreatic Neuroendocrine Tumors | Disease Subtypes | / | ||
| Organ | Pancreas | Test Sample / Technology Platform | Tissue (IHC, FISH, NGS) | ||
| Pathobiological Mechanisms | Components of the chromatin remodeling complex, loss of which leads to substituted prolonged telomeres (ALT) and genomic instability | ||||
| Clinical Availability Status | In clinical validation, 85% of deletion cases had ALT, which was a strong independent prognostic factor for distant metastasis and recurrence. It can be used to distinguish PanNET G3 from PanNEC | ||||
| Notes and Dynamics | The mutations are mutually exclusive, and liquid biopsy to detect cfDNA mutations is the frontier | ||||