Parameter
| Biomarker | RB1 | Full name | Retinoblastoma gene 1 | Molecular Type | Nucleic acid (DNA) |
|---|---|---|---|---|---|
| Molecular Formula | Macromolecule | Molecular Weight | / | Core Functional Dimensions | Diagnosis and prognosis |
| Disease | Pancreatic Neuroendocrine Tumors | Disease Subtypes | / | ||
| Organ | Pancreas | Test Sample / Technology Platform | Tissue (IHC, NGS) | ||
| Pathobiological Mechanisms | Retinoblastoma gene, deletion results in uncontrolled cell cycle and accelerates tumor progression | ||||
| Clinical Availability Status | In clinical validation, PanNEC characteristic deletion combined with TP53 mutation to predict chemotherapy sensitivity; It was used to exclude PanNET G3 | ||||
| Notes and Dynamics | It is a key differential marker for PanNEC and PanNET G3 | ||||