Parameter
| Biomarker | miR-1 / miR-133a | Full name | MicroRNA-1 / MicroRNA-133a-1 | Molecular Type | Noncoding RNA (miRNA) |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | 22 nt | Core Functional Dimensions | Diagnosis, prognosis |
| Disease | Coronary heart disease (CHD) | Disease Subtypes | / | ||
| Organ | Myocardium, skeletal muscle | Test Sample / Technology Platform | Serum/plasma (RT-PCR, real-time PCR, digital PCR) | ||
| Pathobiological Mechanisms | Regulation of cardiomyocyte apoptosis, hypertrophy related genes (such as Bcl-2, IGF-1); The expression of myocardial cells is significantly abnormal after myocardial injury | ||||
| Clinical Availability Status | Clinical validation (auxiliary diagnosis) : multicenter studies confirmed the marked increase in AMI onset within 2 h (a fold change 2.65-10), and cTn were positively correlated (r = 0.7), part of the center for cTn negative patients with early auxiliary diagnosis | ||||
| Notes and Dynamics | MiR-133-a diagnosis of AUC 0.928, is superior to the part of the hs-cTn detection; It has good stability (can be stored for 72 hours in serum) and is suitable for sample transport in remote areas | ||||