Parameter
| Biomarker | Lactate | Full name | Lactic acid | Molecular Type | Metabolites |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | 90.08 Da | Core Functional Dimensions | Diagnosis and Prognosis |
| Disease | Coronary heart disease (CHD) | Disease Subtypes | / | ||
| Organ | All cells (anaerobic metabolism), liver (gluconeogenesis) | Test Sample / Technology Platform | Serum/plasma (colorimetry, enzymatic method, blood gas analyzer) | ||
| Pathobiological Mechanisms | During myocardial ischemia, anaerobic metabolism is enhanced and lactic acid accumulates. It reflects the degree of tissue hypoxia and the disorder of energy metabolism of myocardial cells | ||||
| Clinical Availability Status | Clinical available (emergency evaluation) : in the emergency treatment of chest pain rapid screening process, used for patients with suspected AMI emergency stratification, lactic acid > 2 tendency for prompt severe myocardial ischemia, L need to priority intervention | ||||
| Notes and Dynamics | Within 24 h of the level associated with AMI mortality is (lactate > 4 tendency when L mortality increased 5 times); High negative predictive value (95% accuracy for ruling out critical ischemia at <1mmol/L) | ||||