Parameter
| Biomarker | TET2 mutation | Full name | Ten-Eleven Translocation 2 gene mutation | Molecular Type | Nucleic acid (DNA) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Susceptibility, prognosis | ||
| Disease | Acute Myeloid Leukemia (AML) | Disease Subtypes | / | ||
| Organ | Blood, bone marrow | Test Sample / Technology Platform | Whole blood/bone marrow (genomic sequencing) | ||
| Pathobiological Mechanisms | The encoding methylenecylenine di-oxidase (MCD) gene, when mutated, leads to high DNA methylation, which affects hematopoietic cell differentiation. | ||||
| Clinical Availability Status | Research validation: Coexistence with multiple gene mutations, the prognostic value remains controversial. | ||||
| Notes and Dynamics | Mutations are mutually exclusive with IDH1/2; the mutation may represent an early event in leukemia development, influencing disease progression. | ||||